Test Background Anti-adrenal antibody results are positive in 60-70 % of patients with idiopathic Addison’s disease. Antibodies against adrenal cortex are associated with primary adrenal failure in up to 50 % of patients with Addisonian adrenal insufficiency. Positive antibodies can, however, be an incidental finding or predate the development of hypoadrenalism.
Anti-adrenal antibodies are also present in 28 % of patients with idiopathic hypothyroidism and 7 % of patients with Hashimoto’s disease.
Positive antibodies may also be associated with gonadal failure.
Clinical Indications Raised titres in adrenocortical insufficiency due to an autoimmune disorder (Addison's Disease).