Test Background The NPM1 gene codes for the corresponding protein nucleophosmin. Mutations involving NPM1 can be found in patients with AML and the effect of this mutation is seen in the inactivation of the tumour suppressor p53/ARF pathway.
Clinical Indications Molecular screening for the NPM1 mutation is examined to guide in the formulation of effective treatment plans.
Sample Required Blood or bone marrow in EDTA (lavender top)
Sample Volume 10-20 mL blood3-5 mL bone marrow
Transport/Storage Should reach the laboratory within 72 hours of collection