Imperial Collage Healthcare

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Nucleophosmin (NPM) 1


Test Background
The NPM1 gene codes for the corresponding protein nucleophosmin. Mutations involving NPM1 can be found in patients with AML and the effect of this mutation is seen in the inactivation of the tumour suppressor p53/ARF pathway.


Clinical Indications
Molecular screening for the NPM1 mutation is examined to guide in the formulation of effective treatment plans.


Sample Required
Blood or bone marrow in EDTA (lavender top)


Sample Volume
10-20 mL blood3-5 mL bone marrow


ransport/Storage
Should reach the laboratory within 72 hours of collection


Turnaround Time
10 working days


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