Test Background The chimerism investigation is carried out following haematopoietic stem cell transplants to monitor the proportion of host and donor DNA. A semi-quantitative amplification of informative microsatellites in whole blood and T-cell selected samples is undertaken to obtain a value to indicate the donor recipients transplant status.
Clinical Indications Undertaking an analysis of chimerism is a valuable tool in assessing a patient’s response to transplantation. By observing the chimeric profiles and assessing the donor and recipient ratios, it is possible to determine the success of the transplant and if there is progression or potential to relapse.
Sample Required EDTA (lavender top)
Sample Volume 10-20 mL within 72 hours of collection
Turnaround Time 10 working days