Test BackgroundVitamin B1 (thiamine) is a water-soluble pro-vitamin of thiamine pyrophosphate (TPP), a co-enzyme for several important metabolic enzymes. Mild deficiency results in malaise, weight loss, irritability and confusion. Gross deficiency leads to manifestations of Wernicke-Korsakoff syndrome, with associated cardiovascular and neurological symptoms. A lack of thiamine can be due to malnutrition or malabsorption, with alcoholics and renal dialysis patients at particular risk of deficiency.
Clinical Indications Suspected deficiency in malabsorption syndromes and in patients on parenteral nutrition.
Sample Required EDTA (lavender top) Rush to lab as sample must be frozen as soon as possible – keep in dark
Sample Volume 1 mL
Turnaround Time Up to 6 weeks
NotesNot currently performed in house; this is a referred test.