Test Background Requested for investigations of suspected steroid hormone-secreting tumours, causes of virilisation, ie. enzyme deficiencies that cause a masculine appearance, or in cases of apparent electrolyte imbalance with or without hypertension.
Clinical Indications Diagnosis of CAH (cliteromegaly/ambiguous genitalia of infants or delayed puberty/deranged electrolyte balance in late-onset CAH)
Diagnosis of adrenal hypofunction
Suspected aldosterone resistance/insensitivity
Diagnosis of adrenal tumours (common tumours secrete DHEAS, 11ß-hydroxyandrostenedione and pregnenolone)
Reference Range See report
Sample Required 24 hour urine collection
Spot urine for babies/children
Sample Volume 24 hour urine collection
5 mL for babies/children
Turnaround Time Up to 6 weeks
Notes Not currently performed in house; this is a referred test.
Request should be made or sanctioned by a consultant endocrinologist.