Imperial Collage Healthcare

S-100


Test Background
The S-100 protein family of acidic calcium binding proteins consists of 17 monomers, each of which exhibits a unique pattern of tissue-specific expression. Two of the monomeric proteins, S-100A1 and S-100B, are found in high concentrations in the nervous system of vertebrates. These two monomers form either homo- or hetero-dimers; S-100B is present in high concentrations in glial and Schwann cells. Several studies have demonstrated the value of S-100 in the management of patients with malignant melanoma.


Clinical Indications
Management of patients with malignant melanoma.


Reference Range

<0.15 µg/L


Sample Required
Serum (Red top or SST (gold top)


Sample Volume
1ml (minimum 250µl serum)


Turnaround Time
10 days


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