Test Background Following ovulation the corpus luteum secretes progesterone which prepares and maintains the endometrium for pregnancy. Progesterone concentration >30 nmol/L at mid-luteal phase confirms ovulation and values >20 nmol/L in the luteal phase are highly suggestive of recent ovulation. Progesterone rises during pregnancy, is used to support pregnancy in donor egg cycles, and is occasionally used in diagnosis and monitoring of ectopic pregnancy and miscarriage.
Clinical Indications Confirmation of ovulation
Suspected miscarriage, suspected ectopic pregnancy
Monitoring of progesterone replacement therapy in those undergoing fertility treatment
Reference Range Female follicular: <5 nmol/L
Female luteal: >20 nmol/L