Imperial Collage Healthcare

Oxalate


Test Background
Oxalate is an end product of glycolate and glyoxalate metabolism. Humans have no enzyme capable of degrading oxalate, so it must be eliminated by the kidney. In tubular fluid, oxalate can combine with calcium to form calcium oxalate stones. Increased urinary oxalate excretion promotes calcium oxalate stone formation. Causes of hyperoxaluria include inherited enzyme deficiencies (primary hyperoxaluria), gastrointestinal disorders associated with fat malabsorption (secondary hyperoxaluria) and increased intake of oxalate-rich foods.


Clinical Indications
Monitoring therapy for renal stones Identifying increased urinary oxalate as a risk factor for stone formation Diagnosis of hyperoxaluria


Reference Range

See report


Sample Required
24 hour urine collection acidified or fresh random urine is suitable if acidified promptly on receipt in the laboratory or EDTA (lavender top) on ice rush to laboratory


Sample Volume
24 hour urine collection Random urine: 8 mL (pH <4.0) or 1 mL plasma


Turnaround Time

Urine up to 2 weeks 

Blood up to 3 weeks 


Notes
Not currently performed in house; this is a referred test. Urine oxalate is preferred specimen type when renal function is normal.

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