Test Background Oligoclonal banding analysis is used to aid diagnosis of several neurological disorders, principally that of the demyelinating diseases multiple sclerosis (MS) and Guillain-Barré syndrome. The presence of two or more IgG bands in CSF that are not present in serum constitutes a positive test. Typically about 90 % of MS patients show oligoclonal banding in their CSF.
Clinical Indications Oligoclonal banding is associated with MS, Guillain-Barré, SLE, SAH, neurosarcoidosis, subacute sclerosing panencephalitis, CNS lymphoma and syphilis.
Reference Range CSF IgG: <40 mg/L CSF albumin: <320 mg/L CSF:IgG/alb: <0.25 CSF/serum (IgG/albumin): <0.85 Qualitative isoelectric focusing for oligoclonal IgG
Sample Required CSF and SST (gold top) or serum (red top)
Sample Volume 0.5 mL
Turnaround Time 2 weeks