Imperial Collage Healthcare

Oligoclonal studies

Test Background
Oligoclonal banding analysis is used to aid diagnosis of several neurological disorders, principally that of the demyelinating diseases multiple sclerosis (MS) and Guillain-Barré syndrome. The presence of two or more IgG bands in CSF that are not present in serum constitutes a positive test. Typically about 90 % of MS patients show oligoclonal banding in their CSF.

Clinical Indications
Oligoclonal banding is associated with MS, Guillain-Barré, SLE, SAH, neurosarcoidosis, subacute sclerosing panencephalitis, CNS lymphoma and syphilis.

Reference Range
CSF IgG: <40 mg/L CSF albumin: <320 mg/L CSF:IgG/alb: <0.25 CSF/serum (IgG/albumin): <0.85 Qualitative isoelectric focusing for oligoclonal IgG

Sample Required
CSF and SST (gold top) or serum (red top)

Sample Volume
0.5 mL

Turnaround Time
2 weeks

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