Imperial Collage Healthcare

Oligoclonal studies


Test Background
Oligoclonal banding analysis is used to aid diagnosis of several neurological disorders, principally that of the demyelinating diseases multiple sclerosis (MS) and Guillain-Barré syndrome. The presence of two or more IgG bands in CSF that are not present in serum constitutes a positive test. Typically about 90 % of MS patients show oligoclonal banding in their CSF.


Clinical Indications
Oligoclonal banding is associated with MS, Guillain-Barré, SLE, SAH, neurosarcoidosis, subacute sclerosing panencephalitis, CNS lymphoma and syphilis.


Reference Range

CSF IgG : <40 mg/L
CSF albumin : <320 mg/L
CSF:IgG/alb : <0.25
CSF/serum (IgG/albumin) : <0.85
Qualitative isoelectric focusing for oligoclonal IgG


Sample Required
CSF and SST (gold top) or serum (red top)


Sample Volume
0.5 mL


Turnaround Time
2 weeks


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