Oligoclonal banding analysis is used to aid diagnosis of several neurological disorders, principally that of the demyelinating diseases multiple sclerosis (MS) and Guillain-Barré syndrome. The presence of two or more IgG bands in CSF that are not present in serum constitutes a positive test. Typically about 90 % of MS patients show oligoclonal banding in their CSF.
Oligoclonal banding is associated with MS, Guillain-Barré, SLE, SAH, neurosarcoidosis, subacute sclerosing panencephalitis, CNS lymphoma and syphilis.
|CSF IgG||:|| <40 mg/L
|CSF albumin||:|| <320 mg/L
|CSF/serum (IgG/albumin)||:|| <0.85
|Qualitative isoelectric focusing for oligoclonal IgG|
CSF and SST (gold top) or serum (red top)