Imperial Collage Healthcare

Metanephrines (blood)


Test Background
Metanephrines are biogenic amines derived from COMT metabolism of the catecholamines epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. Metanephrines are measured in the investigation of phaeochromocytoma and paragangliomas since these tumours over express COMT.
Note the test of choice is urine metanephrines. Please only request plasma metanephrines where urine collection is not possible.


Clinical Indications
Screening for phaeochromocytoma in hypertensive individuals with the following:

  • Age <40 years
  • Hyperadrenergic symptoms (episodic headache, sweating, palpitations, anxiety)
  • Adrenal mass/nodule
  • Familial history of MEN-2, VHL, paraganglioma/phaeochromocytoma syndromes


Reference Range

See report


Sample Required
EDTA (lavender top) on ice rush to laboratory
Samples should be taken after 30 minutes rest


Sample Volume
4 mL


Turnaround Time
Up to 6 weeks


Notes
Not currently performed in house; this is a referred test.
Specimen requires prompt separation and freezing.

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