Metanephrines are biogenic amines derived from COMT metabolism of the catecholamines epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. Metanephrines are measured in the investigation of phaeochromocytoma and paragangliomas since these tumours over express COMT.
Note the test of choice is urine metanephrines. Please only request plasma metanephrines where urine collection is not possible.
Screening for phaeochromocytoma in hypertensive individuals with the following:
EDTA (lavender top) on ice rush to laboratory Samples should be taken after 30 minutes rest
Up to 6 weeks
Not currently performed in house; this is a referred test.
Specimen requires prompt separation and freezing.