Imperial Collage Healthcare

Metanephrines (blood)

Lab Code : CHEMRF

Test Background
Metanephrines are biogenic amines derived from COMT metabolism of the catecholamines epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. Metanephrines are measured in the investigation of phaeochromocytoma and paragangliomas since these tumours over express COMT. Note the test of choice is urine metanephrines. Please only request plasma metanephrines where urine collection is not possible.

Clinical Indications
Screening for phaeochromocytoma in hypertensive individuals with the following:

  • Age <40 years
  • Hyperadrenergic symptoms (episodic headache, sweating, palpitations, anxiety)
  • Adrenal mass/nodule
  • Familial history of MEN-2, VHL, paraganglioma/phaeochromocytoma syndromes

Reference Range
See report

Sample Required
EDTA (lavender top) on ice rush to laboratory
Samples should be taken after 30 minutes rest

Sample Volume
4 mL

Turnaround Time
Up to 6 weeks

Not currently performed in house; this is a referred test. Specimen requires prompt separation and freezing.

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