Test BackgroundMetanephrines are biogenic amines derived from COMT metabolism of the catecholamines epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. Metanephrines are measured in the investigation of phaeochromocytoma and paragangliomas since these tumours over express COMT.
Note the test of choice is urine metanephrines. Please only request plasma metanephrines where urine collection is not possible.
Clinical Indications Screening for phaeochromocytoma in hypertensive individuals with the following:
Sample Required EDTA (lavender top) on ice rush to laboratory Samples should be taken after 30 minutes rest
Sample Volume 4 mL
Turnaround Time Up to 6 weeks
NotesNot currently performed in house; this is a referred test.
Specimen requires prompt separation and freezing.