Test Background Metanephrines are biogenic amines derived from COMT metabolism of the catecholamines epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. Metanephrines are measured in the investigation of phaeochromocytoma and paragangliomas since these tumours over express COMT.
Note the test of choice is urine metanephrines. Please only request plasma metanephrines where urine collection is not possible.
Clinical Indications Screening for phaeochromocytoma in hypertensive individuals with the following: