Test Background Manganese is a trace element that is an essential co-factor for several enzymes, including manganese superoxide dismutase, pyruvate carboxylase and isocitrate dehydrogenase. Manganese is typically measured to assess risk of toxicity due to industrial exposure or over-supplementation of Mn in patients on TPN. The symptoms of toxicity are largely neurological and are similar to Parkinson’s disease. Patients with Behçet disease, a form of chronic systemic vasculitis, also exhibit increased blood manganese, and it is suggested that increased activity of superoxide dismutase may contribute to the pathogenesis of the disease.
TPN for >3 months
Unexplained neurological symptoms
Reference Range Plasma: <10 nmol/L Whole blood: 80-200 nmol/L
Sample Required Whole Blood: EDTA trace element free (royal blue top) preferred, standard EDTA (lavender top) acceptable. Urine: sterile universal or plain 24hr collection
Sample Volume 0.5 mL
Turnaround Time 2 weeks