Imperial Collage Healthcare

Macroprolactin


Test Background
Macroprolactinaemia refers to a polymeric form of prolactin in which several molecules form aggregates with circulating IgG. This rarely elicits a biological response due to the inability of such a large molecule to interact with the prolactin receptor, however, it can be detected by immunoassays leading to spurious elevated prolactin results.


Clinical Indications
Differential diagnosis of macroprolactin-associated hyperprolactinaemia with that of prolactinoma, hypothyroidism or drug/stress-induced hyperprolactinaemia, eg. Assayed prolactin >600 mIU/L (female) or >350mIU/L (male) where physiological or pathological causes of hyperprolactinaemia are excluded


Reference Range

See report


Sample Required
SST (gold top) or serum (red top)


Sample Volume
0.5 mL


Turnaround Time
10 days


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