Gastrin is a naturally occurring hormone whose major physiological role is the stimulation of gastric acid secretion. Abnormally high plasma levels of gastrin may indicate Zollinger-Ellison syndrome (along with proven excessive gastric acid secretion). This is of particular interest in patients with persistent ulcer symptoms and also those with suspected familial multiple endocrine neoplasia type 1.
Suspected gastrinoma/somatostatinoma or Zollinger-Ellison syndrome: hypergastrinaemia, dyspepsia, diarrhoea, steatorrhoea, mixed endocrinopathy.
EDTA (lavender top) on ice rush to laboratory
3mL of plasma