Imperial Collage Healthcare


Test Background
Cryoglobulins are proteins that become insoluble at less than -4°C. Cryoglobulinaemia can be associated with various diseases: Type I is most commonly encountered in patients with a plasma cell dyscrasia such as multiple myeloma or Waldenström’s macroglobulinaemia. Types II and III are strongly associated with infection by hepatitis C and some connective tissue autoimmune diseases.

Clinical Indications
Presentation of: arthralgia and joint disease, acrocyanosis, purpura, paraesthesia and peripheral neuropathy or Raynaud’s phenomenon (paroxysmal vasospastic and subsequent vasodilatory sequelae affecting peripheral arterioles usually in the hands and feet; commonly seen in response to cold exposure).

Reference Range

0-20 mg/L

Sample Required
Serum (red top) and EDTA (lavender top)
Samples must be maintained at 37 degrees C. Please contact the site Specimen Reception to arrange collection of pre-warmed tubes.

Sample Volume
8 mL of each sample type

Turnaround Time
2 weeks

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