Imperial Collage Healthcare


Test Background
Cryoglobulins are proteins that become insoluble at less than -4°C. Cryoglobulinaemia can be associated with various diseases: Type I is most commonly encountered in patients with a plasma cell dyscrasia such as multiple myeloma or Waldenström’s macroglobulinaemia. Types II and III are strongly associated with infection by hepatitis C and some connective tissue autoimmune diseases.

Clinical Indications
Presentation of: arthralgia and joint disease, acrocyanosis, purpura, paraesthesia and peripheral neuropathy or Raynaud’s phenomenon (paroxysmal vasospastic and subsequent vasodilatory sequelae affecting peripheral arterioles usually in the hands and feet; commonly seen in response to cold exposure).

Sample Required
Serum (red top) and EDTA (lavender top)
Samples must be maintained at 37 degrees C. Please contact the site Specimen Reception to arrange collection of pre-warmed tubes.
Samples received at room temperature are unsuitable

Sample Volume
8 mL of each sample type

Turnaround Time
2 weeks

Contact the Duty Biochemist/ laboratory before collecting samples.

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