Imperial Collage Healthcare

Copper (urine)


Test Background
Copper is an essential trace element. It is required for ferro-oxidase activity which is an essential stage for incorporation of iron into haem. Copper is absorbed in the intestines and then transported to the liver, where it is stored or used in the production of a variety of enzymes. Caeruloplasmin is a copper-containing enzyme that plays a role in the body’s iron metabolism. In the blood, 95 % is bound to caeruloplasmin and 5 % is free. It is used in conjunction with serum copper assay to help diagnose Wilson’s disease and evaluate copper metabolism.


Clinical Indications

  • Differential diagnosis of apparent Copper­-overload syndromes
  • Monitoring of chelation therapy for treatment of Wilson’s disease and/or copper overload


Reference Range

<1 μmol/24 h


Sample Required
24 hour urine collection


Sample Volume
24 hour urine collection


Turnaround Time
2 weeks


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