Chromagranins are raised in neuroendocrine tumours and can be used for monitoring and detecting recurrence. They are measured as part of the Gut Hormone profile.
Suspected gastrinoma/somatostatinoma or Zollinger-Ellison syndrome: hypergastrinaemia, dyspepsia, diarrhoea, steatorrhoea, mixed endocrinopathy VIPoma: watery diarrhoea, hypokalaemia, achlorhydria, hypotension and flushing/vasodilation Glucagonoma: hyperglycaemia refractory to insulin, skin lesions, diarrhoea and stomatitis
EDTA (lavender top) on ice rush to laboratory
3mL of plasma