Test Background Serum chloride varies as a function of the body’s water and electrolyte homeostasis, in addition to being an index of acid-base. Chloride levels are largely regulated by the action of the kidneys and deranged amounts typically correlate with renal impairment.
Clinical Indications Hyperchloraemia: indicates dehydration and is associated with hypernatraemia. Elevated levels also correspond to metabolic acidosis or respiratory alkalosis (through hyperventilation)
Hypochloraemia: typically associated with hyponatraemia but also occurs with prolonged vomiting or gastric suction, chronic diarrhoea, emphysema, COPD and metabolic alkalosis
Reference Range Blood: 95-108 mmol/L
Urine: no reference interval