Test BackgroundCA 19-9 is a tumour-associated glycoprotein mucin that bears a specific carbohydrate epitope, the sialylated Lewisa blood group antigen. The assay is based upon a monoclonal antibody, 1116-NS-19-9 which recognises this carbohydrate antigenic determinant. Approximately 7 % of the population who have the phenotype Lewisa negative are prevented by their genetic constitution from synthesising CA 19-9 antigen. Serum CA 19-9 concentrations are elevated in 70-92 % of patients with pancreatic carcinomas. This marker may also prove helpful in monitoring treatment response in other CA 19-9 positive carcinomas. CA 19-9 may be elevated in cancers, including hepatocellular, gastric, colorectal, lung and gall bladder cancers. A variety of conditions, including biliary obstruction, cholestasis, cholangitis, hepatic cirrhosis, cystic fibrosis, acute and chronic pancreatitis, may also cause elevation of CA 19-9.
Sample Required Serum (red top) preferred, SST (gold top) acceptable
Sample Volume 0.5 mL
Turnaround Time 4 days