Test BackgroundCA125 is a coelomic cell-surface glycoprotein of 200 kDa that is expressed on cells of serous ovarian carcinoma. CA125 is defined by the OC125 monoclonal antibody. It is expressed predominantly in ovarian cancer, though primary tumours of the endometrium, fallopian tubes, lung, breast, liver or gastrointestinal tract may also give rise to elevations of serum CA125. Many other conditions aside from ovarian cancer may also cause increased levels, notably: endometriosis, menstruation, pelvic inflammatory disease, pregnancy, chronic hepatitis, congestive heart failure and poorly controlled diabetes. Higher levels (>100 kIU/L), or continuously increasing levels, are more specifically associated with ovarian cancer.
Clinical Indications Ovarian cancer
Sample Required Serum (red top) preferred, SST (gold top) accepted
Sample Volume 0.5 mL
Turnaround Time 4 days
NotesAbbott Architect assay