Unconjugated bilirubin, arising from haem metabolism is carried in the blood bound to protein (primarily albumin). This bilirubin is freed from its protein binding in the liver where it is conjugated and excreted. Conjugation and excretion is usually an efficient process. The accumulation of conjugated bilirubin (also called direct) is always pathological.
Investigations of jaundice Differential diagnosis of cholestasis and cholecystitis
|Over 1 month||:||0-5 μmol/L Less than 1 month|
SST (gold top) or heparin (green top)