Imperial Collage Healthcare

Apolipoprotein B (Apo B)

Test Background
One molecule of Apo B lies at the core of the VLDL moiety from which the enzyme lipoprotein lipase progressively removes triglycerides to form LDL. Measurement of Apo B facilitates a stratification of risk for the development of atherosclerotic heart disease in a manner analogous to that of LDL calculation, but not fraught with the same complications, eg. hypertriglyceridaemia hampers indirect inference of LDL from HDL/triglyceride assay.

Clinical Indications
Suspected hyperlipidaemia/hyperlipidaemia Family history of cardiovascular heart disease Unreliable LDL calculation, ie. consistent hypertriglyceridaemia Investigations of the suspected inborn error of metabolism Bassen-Kornzweig syndrome (Apo B deficiency: symptoms include diarrhoea, failure to thrive, neurological disorders and steatorrhoea)

Reference Range
Male: 0.43-1.28 g/L Female: 0.42-1.12 g/L

Sample Required
SST (gold top) or serum (red top)

Sample Volume
0.5 mL

Turnaround Time
1 week

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