Imperial Collage Healthcare

Apolipoprotein B (Apo B)


Test Background
One molecule of Apo B lies at the core of the VLDL moiety from which the enzyme lipoprotein lipase progressively removes triglycerides to form LDL. Measurement of Apo B facilitates a stratification of risk for the development of atherosclerotic heart disease in a manner analogous to that of LDL calculation, but not fraught with the same complications, eg. hypertriglyceridaemia hampers indirect inference of LDL from HDL/triglyceride assay.


Clinical Indications
Suspected hyperlipidaemia/hyperlipidaemia Family history of cardiovascular heart disease Unreliable LDL calculation, ie. consistent hypertriglyceridaemia Investigations of the suspected inborn error of metabolism Bassen-Kornzweig syndrome (Apo B deficiency: symptoms include diarrhoea, failure to thrive, neurological disorders and steatorrhoea)


Reference Range

Male: 0.41 - 1.06 g/L

Female: 0.47 - 0.99 g/L


Sample Required
SST (gold top) or serum (red top)


Sample Volume
0.5 mL


Transport/Storage

Stable at 2-8oC for 72 hours. Please freeze pending dispatch for analysis.

Sample can be sent by first class post.


Turnaround Time
1 week


Notes

Grossly haemolysed samples are unsuitable for this assay.


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