Test Background One molecule of Apo B lies at the core of the VLDL moiety from which the enzyme lipoprotein lipase progressively removes triglycerides to form LDL. Measurement of Apo B facilitates a stratification of risk for the development of atherosclerotic heart disease in a manner analogous to that of LDL calculation, but not fraught with the same complications, eg. hypertriglyceridaemia hampers indirect inference of LDL from HDL/triglyceride assay.
Clinical Indications Suspected hyperlipidaemia/hyperlipidaemia
Family history of cardiovascular heart disease
Unreliable LDL calculation, ie. consistent hypertriglyceridaemia
Investigations of the suspected inborn error of metabolism Bassen-Kornzweig syndrome (Apo B deficiency: symptoms include diarrhoea, failure to thrive, neurological disorders and steatorrhoea)
Reference Range Male: 0.43-1.28 g/L
Female: 0.42-1.12 g/L