Imperial Collage Healthcare

Apolipoprotein A1 (Apo A1)


Test Background
Apo A1 constitutes the major component of high density lipoprotein (HDL). Apo A1 is an activator of the enzyme lecithin:cholesterol acyltransferase and removes free cholesterol from extrahepatic tissues. Apo A1 concentrations correlate with high density lipoprotein cholesterol and thus low levels are a risk factor for coronary artery disease. Rarely, very low levels are seen in hereditary deficiency of LPA1.


Clinical Indications

  • Patients with a personal or family history of high concentrations of lipids and/or premature coronary heart disease
  • Determine cause of high lipid concentrations with suspicion of a deficiency
  • Used with Apo B to check ratio for coronary heart disease risk
  • To monitor effectiveness of changes to lipid-lowering treatment or lifestyle changes


Reference Range

Male : 0.96-1.76 g/L
Female : 1.09-2.03 g/L


Sample Required
SST (gold top) or serum (red top)


Sample Volume
0.5 mL


Turnaround Time
1 week


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