Imperial Collage Healthcare

Apolipoprotein A1 (Apo A1)

Test Background
Apo A1 constitutes the major component of high density lipoprotein (HDL). Apo A1 is an activator of the enzyme lecithin:cholesterol acyltransferase and removes free cholesterol from extrahepatic tissues. Apo A1 concentrations correlate with high density lipoprotein cholesterol and thus low levels are a risk factor for coronary artery disease. Rarely, very low levels are seen in hereditary deficiency of LPA1.

Clinical Indications
Patients with a personal or family history of high concentrations of lipids and/or premature coronary heart disease Determine cause of high lipid concentrations with suspicion of a deficiency Used with Apo B to check ratio for coronary heart disease risk To monitor effectiveness of changes to lipid-lowering treatment or lifestyle changes

Reference Range

Male: 1.22 - 2.13 g/L

Female: 1.31 - 2.33 g/L

Sample Required
SST (gold top) or serum (red top)

Sample Volume
0.5 mL


Stable at 2-8oC for 72 hours. Please freeze pending dispatch for analysis.

Sample can be sent by first class post.

Turnaround Time
1 week


Grossly haemolysed samples are unsuitable for this assay.

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