Test Background AMH can be used to assess ovarian reserve and has the advantage that, compared with FSH, inhibin A/B and ultrasound antral follicular count, levels are relatively unaffected by the menstrual cycle and typically show low intra-individual variation. With respect to Assisted Reproductive Technology (ART), AMH has been used to rationalise treatment regimes in controlled ovarian stimulation, thus reducing risk of hyper-stimulation (OHSS) and often reducing treatment costs.
Clinical Indications Assessment of appropriate stimulation regimes in ART Risk mitigation of OHSS in fertility treatment Occasionally used in differential diagnosis and monitoring of ovarian tumours
Adult males 10.2 – 82.8 pmol/L
AMH levels decline with age and interpretation is therefore most appropriately made by the fertility specialist requesting the test and in conjunction with the antral follicle count.
The following is a general guide
Sample Required Serum (red top) or (gold top) or lithium heparin plasma (green top)
Sample Volume 0.5 mL
Stable at 2-8oC for 24 hours. Please freeze pending dispatch for analysis.
Send to lab frozen.
Falsely low results may be obtained for this test due to biotin interference. Samples should not be taken from patients receiving therapy with high biotin doses (>5 mg/day) until at least 8 hours (ideally 2 days) following the last biotin administration.
Grossly haemolysed samples are unsuitable for this assay.