Imperial Collage Healthcare

Anti-diuretic hormone (ADH)

Test Background
The peptide ADH (arginine vasopressin) is secreted by the hypothalamus in response to increased osmolality of the extracellular fluid compartment and in the intracellular space. The primary function of ADH is to increase the permeability of the collecting duct in the nephron, thereby allowing reabsorbtion and subsequent retention of water down an osmotic gradient and resulting in urine concentration.

Clinical Indications

  • A water-deprivation test should be conducted in lieu of ADH assay for investigations of suspected diabetes insipidus (DI), ie. reduced ADH will fail to rectify diminished water states and thus concentrate urine
  • ADH assay may occasionally be warranted for differential diagnosis of DI (hypothalamic/central DI vs. nephrogenic DI or other causes, eg. psychogenic polydipsia)

Reference Range

See report

Sample Required
Heparin (green top) on ice rush to laboratory

Sample Volume
0.5 mL

Turnaround Time
Up to 6 weeks

Not currently performed in house; this is a referred test.

Filter by A-Z

Select a test from the left to view more details.