Test Background Androstenedione, produced in the adrenal glands and gonads, is a precursor to the androgen testosterone and the oestrogens oestrone and oestradiol. Androstenedione may accumulate in CAH due to 21-hydroxylase or 11β hydroxylase deficiency or in PCOS through increased testosterone turnover. Its secretion may also be elevated by ovarian and adrenal tumours.
Clinical Indications Monitoring treatment of patients with CAH Diagnosis of 17-hydroxysteroid dehydrogenase deficiency. May be useful in differential diagnosis of hyperandrogenism Limited use in diagnosis of CAH, inappropriate to investigations of PCOS
Reference Range 0-9 nmol/L <3 nmol/L prior to adrenarche