Imperial Collage Healthcare

Alpha-1-antitrypsin (A1AT)

Test Background
Familial A1AT deficiency leads to predominantly unrestricted proliferation of neutrophil-mediated elastase in the tissues of the lung, causing extensive collateral damage and subsequent emphysema-like symptoms in adults. Alternatively, neonatal accumulation of dysfunctional A1AT in the liver causes the production of abnormal polymers that damage the surrounding tissues of the liver.

Clinical Indications

  • Unexplained liver cirrhosis in juveniles (and rarely adults)
  • Suspected early-onset emphysema (juveniles/adults) or emphysema with or without family history
  • Observed deficiency as seen on routine serum electrophoresis

Reference Range

Adult : 1.1-2.1 g/L
Newborn : 0.9-2.2 g/L
Less than 6 months : 0.8-1.8 g/L
6 months-1 year : 1.1-2.0 g/L
1-5 years : 1.1-2.2 g/L
5-10 years : 1.4-2.3 g/L
10-15 years : 1.2-2.0 g/L

Sample Required
Serum (red top) or SST (gold top)

Sample Volume
0.5 mL

Turnaround Time
1 week

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