Imperial Collage Healthcare

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Lab Code : HIA

Test Background
5-HIAA is a metabolite of the 5-hydroxytryptamine (5-HT) neurotransmitter (also known as serotonin). Increased 5­HT turnover is characteristic of carcinoid syndrome. Tumours may occur anywhere in the GI tract and can typically secrete 5 HT, catecholamines, prostaglandins and histamine.

Clinical Indications
Carcinoid syndrome, characterised by symptoms of flushing and diarrhoea. Abdominal pain, bronchial asthma, heart failure and pellagra may also be present.

Reference Range
<40 μmol/24 h

Sample Required
24 hour urine collection acidified

Sample Volume
24 hour urine collection

Turnaround Time
2 weeks

Certain foodstuffs may cause false positive results. These include: avocados, bananas, plums, walnuts, pineapples, tomatoes, aubergines and cough mixtures containing glycerol guaiacolate. In the event of a positive result, we would suggest the patient be asked to avoid these foodstuffs for at least 3 days before collecting a repeat sample.

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