IGF-1 is a major regulator of cell growth and differentiation. IGF-1 synthesis is subject to growth hormone (GH) control and occurs predominantly in the liver, though many cell types can and do produce IGF-1 to potentiate localised, paracrine effects. Concentrations of IGF-1 directly correlate with those of GH and are diagnostic of GH excess (acromegaly) and deficiency (dwarfism and related pituitary dysfunction, as well as chronic protein malnutrition/malabsorption).
Suspected acromegaly Suspected dwarfism or suspected pituitary insufficiency
Serum (red top)