Imperial Collage Healthcare

Insulin-like growth factor 1 (IGF1)

Test Background
IGF-1 is a major regulator of cell growth and differentiation. IGF-1 synthesis is subject to growth hormone (GH) control and occurs predominantly in the liver, though many cell types can and do produce IGF-1 to potentiate localised, paracrine effects. Concentrations of IGF-1 directly correlate with those of GH and are diagnostic of GH excess (acromegaly) and deficiency (dwarfism and related pituitary dysfunction, as well as chronic protein malnutrition/malabsorption).

Clinical Indications

  • Suspected acromegaly
  • Suspected dwarfism or suspected pituitary insufficiency

Reference Range

<6 years : 3.5-22 nmol/L
6-8 years : 7-32 nmol/L
9-11 years : 11-52 nmol/L
12-15 years : 14-66 nmol/L
16-20 years : 35-62 nmol/L
21-40 years : 13-50 nmol/L
41-60 years : 9-40 nmol/L
>60 years : 6-36 nmol/L

Sample Required
Serum (red top)

Sample Volume
1 mL

Turnaround Time
1 week

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