Test BackgroundThis procedure can be used for the investigation of inhibitors against specific coagulation factors, usually factors VIII and IX. These inhibitors arise in fewer than 10 % of haemophiliacs. Specific antibodies against coagulation factors vary in specificity and reaction kinetics; some are directed against the active site of the clotting factor molecule, leading to the more severe clinical problems, others against the phospholipid or cofactor binding regions.
Sample Required 3 x 4.5 mL sodium citrate (pale blue top)
Turnaround Time 14 days
NotesSpecial handling: avoid prolonged stasis during venepuncture.
Sample must be received by lab within 2 hours of collection.
Please note: samples will be rejected if underfilled, clotted or haemolysed, or if they come from patients receiving anticoagulant therapy.
Similarly, sampling is inappropriate within 4 weeks post-childbirth, or during an acute phase inflammatory response.