Imperial Collage Healthcare

Haemoglobin H inclusion bodies


Test Background
Haemoglobin H and other unstable haemoglobins readily denature under oxidative stress to form intracellular inclusion bodies. Hb H bodies are looked for in patients suspected of having alpha thalassaemia trait, Hb H disease or an unstable haemoglobin. The Hb H inclusion bodies assay is used to confirm the presence of variants in haemoglobinopathy investigations.


Clinical Indications
Reflexed following haemoglobinopathy screens by Haematology medical or laboratory staff only.
To quickly identify individuals with clinically (genetically) significant forms of alpha thalassaemia.


Sample Required
4 mL EDTA (lavender top) adults
0.5 mL EDTA (lavender top) paediatrics


Sample Volume
0.5 mL adult tube
0.2 mL paediatric tube


Turnaround Time
1-3 days depending on the day of arrival


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