Imperial Collage Healthcare

Factor assays II, V, VII, VIII, IX, X, XI, XII, XIII, collagen binding assay


Test Background

Factor assays can be performed where a coagulation factor deficiency is suspected in order to identify abnormal levels of specific coagulations factors. Factor assays are performed using methods based upon the PT or APTT, which are specific for factors II, V, VII and X or factors VIII, IX, XI and XII, respectively. Factor XIII is performed by a chromogenic method and FVIII can also be assayed by a chromogenic method as an alternative to the APTT based method.
Abnormally low results may be significant in a bleeding diathesis, although factor XII deficiency is not associated with an increased risk of bleeding.
Factor assays can also be used to monitor known haemophiliacs receiving factor concentrate.


Clinical Indications
By approval of Consultant Haematologist

Investigation of a suspected coagulation factor deficiency
Family history of haemophilia
Monitoring pre and post factor concentrate administration


Reference Range





Factor XIII reference range for all ages is 0.64 – 1.76 IU/mL


Sample Required
2.7 mL sodium citrate (pale blue top) adults
1.8 mL sodium citrate (pale blue top) paediatrics


Turnaround Time
14 days


Notes

Please Note: Samples will be rejected if under/over-filled, clotted or haemolysed

Factor XIII assay is performed by The Royal Free Hospital Laboratory

Adult Reference Range:

Note: The reference ranges for use on patients over the age of 16 years, has been locally verified in accordance with CLSI Guideline EP28-A3c through evaluation on representative normal individuals across the sites to reflect our patient population.

Data sourced via Stago from:
Monagle P. et al. Thromb Haemost 2006; 95: 362-372.
Summerhayes R. et al. J Thromb Haemost, 2007; 5, Supp 2: P-M-105.
Summerhayes R. et al. J Thromb Haemost, 2007; 5, Supp 2: P-S-397.

Paediatric Reference Range

Note: Due to the complexity of collecting blood samples for analysis on normal neonates and paediatric patients, the reference ranges for use on patients up to 16 years of age have been taken from published data, from a research study using comparable methodology and equipment as that currently employed in our organisation. Please contact the laboratory for coagulation paediatric ranges.

Data sourced via Stago from:
Monagle P. et al. Thromb Haemost 2006; 95: 362-372.
Summerhayes R. et al. J Thromb Haemost, 2007; 5, Supp 2: P-M-105.
Summerhayes R. et al. J Thromb Haemost, 2007; 5, Supp 2: P-S-397.


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