Imperial Collage Healthcare

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Factor assays II, V, VII, VIII, IX, X, XI, XII, XIII, high molecular weight kininogen, prekallikrein, collagen binding assay


Lab Code : II, V, VII, VIII, IX, X, XI, XII, XIII, HMWK, PRK, COLBAS


Test Background

Factor assays can be performed where a coagulation factor deficiency is suspected in order to identify abnormal levels of specific coagulations factors. Factor assays are performed using methods based upon the PT or APTT, which are specific for factors II, V, VII and X or factors VIII, IX, XI and XII, respectively. Factor XIII is performed by a chromogenic method and FVIII can also be assayed by a chromogenic method as an alternative to the APTT based method.
Abnormally low results may be significant in a bleeding diathesis, although factor XII deficiency is not associated with an increased risk of bleeding.
Factor assays can also be used to monitor known haemophiliacs receiving factor concentrate.


Clinical Indications
By approval of Consultant Haematologist

Investigation of a suspected coagulation factor deficiency
Family history of haemophilia
Monitoring pre and post factor concentrate administration


Reference Range

                                    Adult (>6 months)         Paediatric (< 6months)
Factor 2 (II)                   0.50 – 1.50 IU/mL         0.60 - 1.09 IU/mL
Factor 5 (V)                   0.50 – 1.50 IU/mL         0.56 - 1.48 IU/mL
Factor 7 (VII)                 0.50 – 1.50 IU/mL          0.38 - 1.29 IU/mL
Factor 8 (VIII),               0.45 – 1.50 IU/mL          0.67 - 1.41 IU/mL
One-stage/Chromogenic  
Factor 9 (IX)                   0.50 – 1.50 IU/mL          0.44 - 0.78 IU/mL
Factor 10 (X)                  0.70 – 1.50 IU/mL          0.55 - 1.20 IU/mL
Factor 11 (XI)                 0.70 – 1.50 IU/mL          0.57 - 1.05 IU/mL
Factor 12 (XII)                0.50 – 1.50 IU/mL          0.28 - 1.16 IU/mL
Factor 13 (XIII) assay     0.68 – 1.34 IU/mL          0.60 - 1.09 IU/mL


Sample Required
4.5 mL sodium citrate (pale blue top) adults
1.8 mL sodium citrate (pale blue top) paediatrics


Turnaround Time
14 days


Notes

Please Note: Samples will be rejected if under/over-filled, clotted or haemolysed


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