Imperial Collage Healthcare

Cryohaemolysis


Test Background
Red blood cells with membrane defects that occur in hereditary spherocytosis are more susceptible to lysis when subjected to severe cold. Increased levels of haemolysis can also be found in stomatocytosis.


Clinical Indications

  • Suspected hereditary spherocytosis
  • Suspected stomatocytosis


Reference Range

Normal range <2 %
A result of >8 % is diagnostic of hereditary spherocytosis


Sample Required
4 mL EDTA (lavender top) adults
0.5 mL EDTA (lavender top) paediatrics


Sample Volume
0.5 mL adult tube
0.2 mL paediatric tube


Turnaround Time
24 hours


Notes
Samples must be tested within 24 hours of collection

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