Imperial Collage Healthcare

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Test Background
Red blood cells with membrane defects that occur in hereditary spherocytosis are more susceptible to lysis when subjected to severe cold. Increased levels of haemolysis can also be found in stomatocytosis.

Clinical Indications
Suspected hereditary spherocytosis Suspected stomatocytosis

Reference Range
Normal range <2 % A result of >8 % is diagnostic of hereditary spherocytosis

Sample Required
4 mL EDTA (lavender top) adults 0.5 mL EDTA (lavender top) paediatrics

Sample Volume
0.5 mL adult tube 0.2 mL paediatric tube

Turnaround Time
24 hours

Samples must be tested within 24 hours of collection

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