Imperial Collage Healthcare

von Willebrand screen


Test Background
Von Willebrand disease (vWD) is the commonest inherited bleeding disorder, affecting up to 1 % of individuals, irrespective of gender or ethnicity. It comprises a number of types, all of which are characterised by a bleeding defect that resembles a platelet function defect, as platelet adhesion is impaired. The von Willebrand factor (vWF) also serves as a carrier protein for factor VIII and levels of factor VIII are often decreased when vWF levels are decreased. vWD is usually inherited as an autosomal dominant condition.


Clinical Indications
Bleeding diathesis/hypocoagulopathy with presentations of epistaxis, menorrhagia and GI haemorrhaging Differential diagnosis of haemophilia and other forms of bleeding diathesis


Reference Range

FVIII 45-150 IU/dl vWF antigen 45-150 IU/dl vWF : Rco 45-150 IU/dl Collagen binding assay 45-150 IU/dl vW multimers see report


Sample Required
3 x 4.5 mL sodium citrate (pale blue top) adults3 x 1.8 mL sodium citrate (pale blue top) paediatrics


Turnaround Time
14 days


Notes
Special handling: avoid prolonged stasis during venepuncture. Sample must be received by lab within 4 hours of collection. Please note: samples will be rejected if underfilled or overfilled.

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