Test BackgroundThe thrombophilia screen includes the following:
• coagulation screen
• lupus anticoagulant
• protein C
• protein S
• antithrombin assays
• Factor V Leiden
• Prothrombin gene mutation testing
|PT 9-12 s
|APPT 23-31 s
|Fibrinogen 1.8-4.0 g/L
|TT 13-19 s
|Protein C 70-140 IU/dL
|Protein S free (F) 50-110 IU/dL
|Protein S free (M) 70-120 IU/dL
|Antithrombin activity 80-120 IU/dL|
Sample Required 4 x 4.5 mL sodium citrate (pale blue top) adults
4 x 1.8 mL sodium citrate (pale blue top) paediatrics
Plus 1 x 4 mL EDTA (lavender top) adults
or 1 x 0.5 mL EDTA (lavender top) paediatrics
Turnaround Time 10-14 days
NotesSpecial handling: avoid prolonged stasis during venepuncture.
Sample must be received by lab within 2 hours of collection.
Please note: sodium citrate samples will be rejected if underfilled, clotted, haemolysed or if patients are receiving anticoagulant therapy. Similarly, sampling is inappropriate within 4 weeks post-childbirth or during an acute phase inflammatory response.
See cardiolipin antibodies and β2-glycoprotein antibodies, Immunology, Factor V Leiden and prothrombin gene mutation, Molecular Diagnostics.