Imperial Collage Healthcare

Donath-Lansteiner test (for paroxysmal cold haemoglobinuria)


Test Background
Paroxysmal cold haemoglobinuria (PCH) is an autoimmune haemolytic anaemia caused by cold-reacting immunoglobulins. It primarily affects children and tends to cause quite severe, but transient, disease.


Clinical Indications
Presence of a biphasic antibody that binds to the red cells in the cold and lyses the red cell at 37 °C.


Reference Range

Not applicable


Sample Required
EDTA (lavender top)


Sample Volume
4 mL for paediatrics6 mL for adults


Turnaround Time
Dependent on clinical requirement. Contact the laboratory to discuss further.


Notes
This test is referred to the NHS Blood and Transplant service

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